CL CL-F CL-SFRumapel
The different Kollidon® CL grades can best be distinguished by their different particle sizes Average particle size range µm Kollidon® CL 110–130 Kollidon® CL-F 20–40 Kollidon® CL-SF 10–30 Kollidon® CL-M 3–10 All CL-grades are crosslinked wa-ter-insoluble polivinylpyrrolidones. There are chemical but mainly physical crosslinks.
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Study of Binary and Ternary Solid Dispersion of
The dissolution rate is affected by state and size of the particle and the carrier within which it is enclosed. The reduction Again Effect of combination of Poloxamer 407 and Batch Spironolactone Poloxamer 407 HPMC 6 cps HPC Kollicoat IR Kollidon VA 64 I 0.3 g 0.7 g-- II 0.5 g 0.5 g--
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Effects of particle size of yellow dent corn on physical
The model included particle size and the particle size interaction as fixed effects and block as the random effect. However interactions between diet and were not significant for the response variables analyzed except for ADFI from d 0 to 29 and G F from d 29 to 58 and from d 0 to 93.
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Effect of Kollidon VA®64 particle size and morphology as
Effect of Kollidon VA®64 particle size and morphology as directly compressible excipient on tablet compression properties. 64 particle size and morphology as directly compressible.
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Technical InformationBASF
polymers such as Kollidon® VA 64. The comparison is shown in Figure 12. Temperature °C Viscosity Pa · s Soluplus® Kollidon® VA 64 Kollidon® 12 PF 1 000 120 140 160 180 200 220 240 10 100 10 000 100 000 Figure 12 Rotary viscosimeter plate-plate method angular frequency 1.6 rad/s
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Action of polystyrene nanoparticles of different sizes on
Jul 12 2012 · Oberdorster G Ferin J Lehnert BE Correlation between particle size in vivo particle persistence and lung injury. Environ Health Perspect 1994 102(Suppl 5) 173–179. 10.1289/ehp.94102s5173. PubMed Central PubMed Article Google Scholar 11.
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Study of Binary and Ternary Solid Dispersion of
The dissolution rate is affected by state and size of the particle and the carrier within which it is enclosed. The reduction Again Effect of combination of Poloxamer 407 and Batch Spironolactone Poloxamer 407 HPMC 6 cps HPC Kollicoat IR Kollidon VA 64 I 0.3 g 0.7 g-- II 0.5 g 0.5 g--
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A comparative study between hot-melt extrusion and spray
Jul 10 2018 · Both Kollidon® VA 64 and Soluplus® were evaluated in this investigation as carriers for oral immediate release formulations. When incorporated into other formulations these polymers have been shown to significantly increase the drug dissolution rate (Fule et al. 2016 Shamma and Basha 2013 Song et al. 2013).Table 2 shows the composition of each formulation in the current study
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Effect of Particle Size and Polymer Loading on Dissolution
Nov 22 2018 · The effect of particle size on the dissolution behavior of the particles of amorphous solid dispersions (ASDs) of griseofulvin (GF) with 0 -50 Kollidon® VA 64 as a crystallization inhibitor is investigated. Both the final dissolved GF concentration and the dissolution rate of GF ASDs were found to be inversely proportional to the particle size.
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ExAct 2 si RZ
Kollidon VA 64 (Copovidone) is a copolymer of 60 wt. N-vinylpyrrolidone and 40 wt. Besides intrinsic physical properties the particle size distribution has a marked effect on application proper-ties. Pharma quality means that all Kollidon grades This effect is based on the ability
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le Application of a convenient and cost‑effective IC
of water on flow properties of granules as well as an effect of mixing time on surface morphology of granules was studied. Paracetamol (PCM) immediate release granules were prepared using conventional excipients such as polyvinylpyrrolidone K‑30 Kollidon VA 64 (as binders) and simple equipments by MADG technique.
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Technical InformationBASF
polymers such as Kollidon® VA 64. The comparison is shown in Figure 12. Temperature °C Viscosity Pa · s Soluplus® Kollidon® VA 64 Kollidon® 12 PF 1 000 120 140 160 180 200 220 240 10 100 10 000 100 000 Figure 12 Rotary viscosimeter plate-plate method angular frequency 1.6 rad/s
Get PriceSpray drying ternary amorphous solid dispersions of
Nov 01 2017 · It should be mentioned that the ratio of the excipients (HPMCP-HP55 and Kollidon VA 64) was kept at 1 1 for all compositions. Final yield residual solvent content particle size distribution density phase structure and morphology were analysed after spray drying. Table 1 shows the experimental design matrix.
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In this study we use a model ASD composed of a hydrophobic drug with Kollidon in addition to ionic effects it also depends on other factors like particle size and dissolution rate of the salts. This highlights the dynamic nature of the tablet disintegration process which is
Get PriceStructure and dry binding activity of different polymers
The dry binding activity of copolyvidone (Kollidon VA 64) povidone (Kollidon 30) microcrystalline cellulose (Avicel PH-101) hydroxypropylmethylcellulose (HPMC) 2910 (Pharmacoat 606) and maltodextrin (Maldex 18) was investigated using a variety of formulations and methods. The effect of
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Hot-Melt Extrusion withBASF
9.1 Kollidon® VA 64 / VA 64 Fine 85 9.2 Soluplus® 86 9.3 Kollidon® 12 PF Kollidon® 17 PF Kollidon® 30 and 88 Kollidon® 90 F 9.4 Kollidon® SR 91 9.5 Kollicoat® MAE 100P 92 9.6 Kollicoat® IR and Kollicoat® Protect 94 9.7 Kolliphor® P 407 Kolliphor® P 407 micro (Poloxamer 407) 97 and Kolliphor® P 188 Kolliphor® P 188 micro
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Technical Information Soluble Kollidon January 2004
the direct compression of tablets the particle-size distribution of the solid ingredients used is a factor of some signifi cance. The following table gives some typical particle-size distribution values (determined in an air-jet sieve 5 min 20 mbar) Table 5 Particle-size distribution < 50 > 250 Kollidon 25/30 approx. 10 max. 5
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Technical Information Soluble Kollidon January 2004
the direct compression of tablets the particle-size distribution of the solid ingredients used is a factor of some signifi cance. The following table gives some typical particle-size distribution values (determined in an air-jet sieve 5 min 20 mbar) Table 5 Particle-size distribution < 50 > 250 Kollidon 25/30 approx. 10 max. 5
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2College of Pharmacy University of Rhode Island Kingston
Kollidon VA 64 86.4 81.8 Lutrol F 68 9.0 9.1 Dissolution Dissolution profiles of various size fractions of 9.1 w/w resveratrol HME formulation. Methodology Dissolution studies were carried out in a Vankel VK 7020 USP Type II apparatus. Physical mixtures (PM) or hot-melt extrusion formulations (HME) were loaded into hard gelatin
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Olopatadine hydrochloride loaded Kollidon® SR
Jun 01 2019 · Methods. OLO-loaded Kollidon ® SR nanoparticles were prepared using the spray-drying method. The active agent was quantified using ultra-high performance liquid chromatography (U-HPLC). The nanoparticles were characterized according to entrapment efficiency particle size zeta potential morphology solid-state characterizations and drug release.
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Technical InformationBASF
polymers such as Kollidon® VA 64. The comparison is shown in Figure 12. Temperature °C Viscosity Pa · s Soluplus® Kollidon® VA 64 Kollidon® 12 PF 1 000 120 140 160 180 200 220 240 10 100 10 000 100 000 Figure 12 Rotary viscosimeter plate-plate method angular frequency 1.6 rad/s
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How can I solve the problem of low hardness tablet that
The study evaluates use of Kollidon VA(®) 64 and a combination of Kollidon VA(®) 64 with Kollidon VA(®) 64 Fine as excipient in direct compression process of tablets.
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Effect of Particle Size Distribution on Powder Packing and
Jun 01 2017 · Compared with the 15 μm powder (median size of 17.0 μm) the 30 5 μm powder mixture has a similar median particle size (17.4 μm) but a wider distribution which results in a 4.0 more dense green parts and a 7.5–11.7 more dense sintered parts depends on
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Influence of the particle size of copovidone and
and vinyl acetate) were chosen for this study Kollidon® VA ®64 and Kollidon® VA CL (wet)64 Fine. Beside differences in the morphology Kollidon ® VA 64 and Kollidon VA 64 Fine differ mainly in their particle size distribution (Table 2). Table Kollidon3 summarizes typical particle size
Get PriceDrug Development and Industrial Pharmacy Vol 44 No 1
Effect of Kollidon VA ® 64 particle size and morphology as directly compressible excipient on tablet compression properties R. S. Chaudhary C. Patel V. Sevak M. Chan Pages 19-29
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Development of amorphous dispersions of artemether with
state 29 and the particle morphology of pharmaceutical systems 30 . The present study aims to elucidate the potential of en-hancing the solubility and dissolution rate of ARM using hydrophilic polymers like Soluplus KollidonVA 64 HPMC and Eudragit EPO by spray-drying technology. Kollidon VA 64 is a
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Pharmaceutics Free Full-Text Formulation of Sustained
To determine particle size by means of the sieve test the grain size of a 100 g sample is measured by subjecting a sieve stack to vibration for 10 min at speed 10 (CISA ® vibrator). The sieve sizes used are 0.355 mm 0.212 mm 0.100 mm and 0.05 mm.
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A comparative study between hot-melt extrusion and spray
Jul 10 2018 · Both Kollidon® VA 64 and Soluplus® were evaluated in this investigation as carriers for oral immediate release formulations. When incorporated into other formulations these polymers have been shown to significantly increase the drug dissolution rate (Fule et al. 2016 Shamma and Basha 2013 Song et al. 2013).Table 2 shows the composition of each formulation in the current study
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How Does the Addition of Kollidon ® VA64 Inhibit the
Particle size and morphology of solid dispersions were determined using a Phenom Pro desktop electron microscope (PhenomWorld Thermo Fisher Scientific Waltham MA USA) equipped with a CeB 6 electron source and a backscattered electron detector. The powder was placed on the conductive adhesive tape previously glued to a specimen mount.
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